A dynamic system for delivering controlled bromine and chlorine vapor exposures to weanling swine skin.

Published on May 22, 2014in Cutaneous and Ocular Toxicology1.385
· DOI :10.3109/15569527.2013.806524
Thomas H. Snider6
Estimated H-index: 6
(Battelle Memorial Institute),
Mark R. Perry4
Estimated H-index: 4
(Battelle Memorial Institute)
+ 4 AuthorsJohn S. Graham18
Estimated H-index: 18
AbstractContext: Assessing the hazards of accidental exposure to toxic industrial chemical (TIC) vapors and evaluating therapeutic compounds or treatment regimens require the development of appropriate animal models.Objective: The objective of this project was to develop an exposure system for delivering controlled vapor concentrations of TICs to the skin of anesthetized weanling pigs. Injury levels targeted for study were superficial dermal (SD) and deep dermal (DD) skin lesions as defined histopathologically.Materials and methods: The exposure system was capable of simultaneously delivering chlorine or bromine vapor to four, 3-cm diameter exposure cups placed over skin between the axillary and inguinal areas of the ventral abdomen. Vapor concentrations were generated by mixing saturated bromine or chlorine vapor with either dried dilution air or nitrogen.Results: Bromine exposure concentrations ranged from 6.5 × 10−4 to 1.03 g/L, and exposure durations ranged from 1 to 45 min. A 7-min skin exposure to b...
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