Review paper
The ADAM metalloproteinases
Abstract
The ADAMs (a disintegrin and metalloproteinase) are a fascinating family of transmembrane and secreted proteins with important roles in regulating cell phenotype via their effects on cell adhesion, migration, proteolysis and signalling. Though all ADAMs contain metalloproteinase domains, in humans only 13 of the 21 genes in the family encode functional proteases, indicating that at least for the other eight members, protein–protein interactions...
Paper Details
Title
The ADAM metalloproteinases
Published Date
Oct 1, 2008
Volume
29
Issue
5
Pages
258 - 289
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