Review paper
Advanced Glycation End Products and Diabetic Nephropathy
Abstract
Chronic hyperglycemia and oxidative stress in diabetes results in the formation and accumulation advanced glycation end products (AGEs). AGEs have a wide range of chemical, cellular, and tissue effects that contribute to the development of microvascular complications. In particular, AGEs appear to have a key role in the diabetic nephropathy. Their importance as downstream mediators of tissue injury in diabetic kidney disease is demonstrated by...
Paper Details
Title
Advanced Glycation End Products and Diabetic Nephropathy
Published Date
Nov 1, 2005
Volume
12
Issue
6
Pages
562 - 572
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