Vancomycin and ceftazidime incompatibility upon intravitreal injection

Editor,—The recommended treatment of endophthalmitis includes intravitreal injection of broad spectrum antibiotics. Vancomycin is the drug of choice for Gram positive bacteria, while Gram negative coverage can be obtained by either amikacin or ceftazidime. Owing to potential retinal toxicity with amikacin, the option of its substitution by ceftazidime seemed very attractive.1-7 Fiscella,8 and the pharmacological handbooks have already...