M1 MUSCARINIC AGONISTS AND A MULTIPOTENT ACTIVATOR OF SIGMA1/M1 MUSCARINIC RECEPTORS: FUTURE THERAPEUTICS OF ALZHEIMER'S DISEASE

Activation of the M1 muscarinic receptor (M1mAChR) may be beneficial against cognitive deficits and pathologies of Alzheimer's disease (AD) and therefore M1 muscarinic agonists are considered rational treatment strategies. We have further hypothesized that synchronized activation of the M1mAChR and the molecular chaperone sigma-1 receptor (Sig1R) may have broader therapeutic benefits. The M1 selective muscarinic orthosteric agonists AF102B...