Mycelium

Rhizophora mucronata

Fungus

Mangrove

Stereochemistry

Biology

Plant use of endophytic fungi in defense

Chemistry

Ecology

Pestalotiopsis

Rhizophoraceae

Botany

Journal of Natural Products

Six new chromones, named pestalotiopsones A−F (1−6), and the known derivative 7-hydroxy-2-(2-hydroxypropyl)-5-methylchromone (7) were obtained from the mycelia and culture filtrate of the mangrove endophytic fungus Pestalotiopsis sp., which was isolated from leaves of the Chinese Mangrove plant Rhizophora mucronata. Their structures were elucidated on the basis of spectroscopic data. Pestalotiopsones A−F are chromones having both an alkyl side chain substituted at C-2 and a free or substituted carboxyl group at C-5. Compound 6 exhibited moderate cytotoxicity against the murine cancer cell line L5178Y, whereas the other investigated compounds proved to be inactive.

Chromones from the Endophytic Fungus <i>Pestalotiopsis</i> sp. Isolated from the Chinese Mangrove Plant <i>Rhizophora mucronata</i>

Chromones from the Endophytic Fungus Pestalotiopsis sp. Isolated from the Chinese Mangrove Plant Rhizophora mucronata