Hemodynamics

Intensive care medicine

Emergency medicine

Microcirculation

Sepsis

Shock (circulatory)

Cardiology

Heart rate

Anesthesia

Esmolol

Blood pressure

Inotrope

Mathematics

Internal medicine

Geometry

Medicine

Chronotropic

Septic shock

Reduction (mathematics)

Critical Care

Preclinical and clinical studies report that β-blockers may be an interesting option to attenuate the deleterious effects of prolonged catecholamine exposure during septic shock. Nevertheless, there are concerns that β-blockers may have negative chronotropic and inotropic effects leading to inappropriately low cardiac output. The objective of the present study was therefore to elucidate whether a reduction in heart rate (HR) with esmolol may negatively affect microcirculation in patients with septic shock who remained tachycardic after hemodynamic optimization.

Heart rate reduction with esmolol in septic shock: effects on microcirculation