Bacillus anthracis Secretes Proteins That Mediate Heme Acquisition from Hemoglobin
Abstract
Acquisition of iron is necessary for the replication of nearly all bacterial pathogens; however, iron of vertebrate hosts is mostly sequestered by heme and bound to hemoglobin within red blood cells. In Bacillus anthracis, the spore-forming agent of anthrax, the mechanisms of iron scavenging from hemoglobin are unknown. We report here that B. anthracis secretes IsdX1 and IsdX2, two NEAT domain proteins, to remove heme from hemoglobin, thereby...
Paper Details
Title
Bacillus anthracis Secretes Proteins That Mediate Heme Acquisition from Hemoglobin
Published Date
Aug 22, 2008
Journal
Volume
4
Issue
8
Pages
e1000132 - e1000132
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