Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011

Published on Jan 5, 2012in Modern Rheumatology2.113
· DOI :10.1007/S10165-011-0571-Z
Hisanori Umehara43
Estimated H-index: 43
(Kanazawa Medical University),
Kazuichi Okazaki68
Estimated H-index: 68
(Kansai Medical University)
+ 23 AuthorsHirotaka Ohara42
Estimated H-index: 42
(Nagoya City University)
Sources
Abstract
Background IgG4-related disease (IgG4-RD) is a novel clinical disease entity characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration by IgG4+ plasma cells. Although IgG4-RD is not rare and is clinically important, its clinical diagnostic criteria have not been established. Comprehensive diagnostic criteria for IgG4-RD, including the involvement of various organs, are intended for the practical use of general physicians and nonspecialists.
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IgG4-related disease (IgG4-RD) is considered a systemic, chronic, and inflammatory disorder that is characterized by the enlargement of involved organs, elevated levels of IgG4, and abundant infiltration of plasmacytes with IgG4 and fibrosis in involved organs. It is necessary to differentiate IgG4-RD from malignant tumors. Recently we have looked at case reports of IgG4-RD with malignancy that was discovered at systemic screening. In this study, we analyzed the relationship between IgG4-RD and ...
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