Development of Small Molecule Inhibitors and Probes of Human SUMO Deconjugating Proteases
Abstract
Sentrin specific proteases (SENPs) are responsible for activating and deconjugating SUMO (Small Ubiquitin like MOdifier) from target proteins. It remains difficult to study this posttranslational modification due to the lack of reagents that can be used to block the removal of SUMO from substrates. Here, we describe the identification of small molecule SENP inhibitors and active site probes containing aza-epoxide and acyloxymethyl ketone (AOMK)...
Paper Details
Title
Development of Small Molecule Inhibitors and Probes of Human SUMO Deconjugating Proteases
Published Date
Jun 1, 2011
Journal
Volume
18
Issue
6
Pages
722 - 732
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