A method for atlas-based volumetric registration with surface constraints for optical bioluminescence tomography in small animal imaging

Atlases are normalized representations of anatomy that can provide a standard coordinate system for in vivo imaging studies. For Optical Bioluminescence Tomography (OBT) in small animals, the animal's surface topography can be reconstructed from structured light measurements, but internal anatomy is unavailable unless additional CT or MR images are acquired. We present a novel method for estimating the internal organ structure of a mouse by...