ALS-Plus syndrome: Non-pyramidal features in a large ALS cohort

ObjectiveAutopsy studies show widespread pathology in amyotrophic lateral sclerosis (ALS), but clinical surveys of multisystem disease in ALS are rare. We investigated ALS-Plus syndrome, an understudied group of patients with clinical features extending beyond pyramidal and neuromuscular systems with or without cognitive/behavioral deficits.MethodsIn a large, consecutively-ascertained cohort of 550 patients with ALS, we documented atypical...