Original paper
TRPA1 is required for TGF-β signaling and its loss blocks inflammatory fibrosis in mouse corneal stroma
Abstract
We examined whether the loss of transient receptor potential ankyrin 1 (TRPA1), an irritant-sensing ion channel, or TRPA1 antagonist treatment affects the severity inflammation and scarring during tissue wound healing in a mouse cornea injury model. In addition, the effects of the absence of TRPA1 on transforming growth factor β1 (TGF-β1)-signaling activation were studied in cell culture. The lack of TRPA1 in cultured ocular fibroblasts...
Paper Details
Title
TRPA1 is required for TGF-β signaling and its loss blocks inflammatory fibrosis in mouse corneal stroma
Published Date
Sep 1, 2014
Journal
Volume
94
Issue
9
Pages
1030 - 1041
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Notes
History