Original paper
Prostaglandin D2 pathway upregulation: Relation to asthma severity, control, and TH2 inflammation
Volume: 131, Issue: 6, Pages: 1504 - 1512.e12
Published: Jun 1, 2013
Abstract
Bronchoalveolar lavage (BAL) fluid prostaglandin D₂(PGD₂) levels are increased in patients with severe, poorly controlled asthma in association with epithelial mast cells (MCs). PGD₂, which is generated by hematopoietic prostaglandin D synthase (HPGDS), acts on 3 G protein-coupled receptors, including chemoattractant receptor-homologous molecule expressed on TH2 lymphocytes (CRTH2) and PGD₂ receptor 1 (DP1). However, much remains to be...
Paper Details
Title
Prostaglandin D2 pathway upregulation: Relation to asthma severity, control, and TH2 inflammation
Published Date
Jun 1, 2013
Volume
131
Issue
6
Pages
1504 - 1512.e12
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Notes
History