Original paper
Study of the binding interaction between fluorinated matrix metalloproteinase inhibitors and Human Serum Albumin
Abstract
Fluorinated, arylsulfone-based inhibitors of Matrix Metalloproteinases (MMP) have been used, in the [18F]-radiolabelled version, as radiotracers targeted to MMP-2/9 for Positron Emission Tomography (PET). Although they showed acceptable tumour uptake, specificity was rather low. To get further insights into the reason of low specificity, the binding interaction of these compounds with Human Serum Albumin (HSA) has been investigated. 19F NMR...
Paper Details
Title
Study of the binding interaction between fluorinated matrix metalloproteinase inhibitors and Human Serum Albumin
Published Date
May 1, 2014
Journal
Volume
79
Pages
13 - 23
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Notes
History