Risk factor panels associated with hypertension in obstructive sleep apnea patients with different body mass indexes

Published on May 1, 2015in Journal of The American Society of Hypertension2.268
· DOI :10.1016/J.JASH.2015.01.015
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Abstract
Abstract Although hypertension (HTN), obstructive sleep apnea (OSA), and obesity frequently co–occur, the precise role of obesity in this interrelationship is not completely understood. A total of 727 OSA patients were assigned to body mass index (BMI) n  = 201), 25≤ BMI n  = 388), and BMI ≥30 (19%; n  = 138). HTN risk factors in each group were evaluated. A total of 244 (33.6%) patients exhibited co–morbid HTN, of whom 20.5% (50/244), 52.9% (129/244), and 26.6% (65/244) were distributed between the BMI
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Obstructive sleep apnea (OSA) is highly associated with hypertension. However, the correlation between hypertension and OSA at different levels of severity and the influence of gender on that correlation are unclear. A total of 996 patients (776 males and 190 females) with OSA were recruited. The influence of gender on the correlation between hypertension and OSA at different stratifications of severity, based on the apnea-hypopnea index (AHI), was fully evaluated together with the major health ...
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#1Kamal Rahmouni (Roy J. and Lucille A. Carver College of Medicine)H-Index: 64
The worldwide epidemic of excess body weight, including overweight and obesity, is associated with increased prevalence of cardiovascular risks comprising hypertension—a condition that promotes stroke, heart disease, and end-stage organ damage, which are major causes of death and disability.1,2 The close relationship between excess adipose mass and hypertension is well documented, with population-based studies showing excess adiposity as the strongest known risk factor for hypertension in male a...
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#1Tomas Konecny (Mayo Clinic)H-Index: 17
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Rationale: Obstructive sleep apnea and systemic hypertension (SH) are highly prevalent. Although their association has been suggested in cross-sectional studies, conflicting evidence has emerged from longitudinal studies.Objectives: To assess the association between obstructive sleep apnea and SH in the middle-aged general population.Methods: A total of 2,148 subjects were included in a longitudinal study of the Vitoria Sleep Cohort, a general population sample aged 30–70 years. We analyzed data...
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Purpose: To investigate the role of sodium–hydrogen exchanger-1 (NHE-1) and exercise training on intermittent hypoxia-induced cardiac fibrosis in obstructive sleep apnea (OSA), using an animal model mimicking the intermittent hypoxia of OSA. Methods: Eight-week-old male Sprague–Dawley rats were randomly assigned to control (CON), intermittent hypoxia (IH), exercise (EXE) or IH combined with exercise (IHEXE) groups. These groups were randomly assigned to subgroups receiving either a vehicle or th...
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