Risk factor panels associated with hypertension in obstructive sleep apnea patients with different body mass indexes

Published on May 1, 2015in Journal of The American Society of Hypertension2.268
· DOI :10.1016/J.JASH.2015.01.015
Yi Lu
Sources
Abstract
Abstract Although hypertension (HTN), obstructive sleep apnea (OSA), and obesity frequently co–occur, the precise role of obesity in this interrelationship is not completely understood. A total of 727 OSA patients were assigned to body mass index (BMI) n  = 201), 25≤ BMI n  = 388), and BMI ≥30 (19%; n  = 138). HTN risk factors in each group were evaluated. A total of 244 (33.6%) patients exhibited co–morbid HTN, of whom 20.5% (50/244), 52.9% (129/244), and 26.6% (65/244) were distributed between the BMI
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#1Qiang YuH-Index: 3
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Obstructive sleep apnea (OSA) is highly associated with hypertension. However, the correlation between hypertension and OSA at different levels of severity and the influence of gender on that correlation are unclear. A total of 996 patients (776 males and 190 females) with OSA were recruited. The influence of gender on the correlation between hypertension and OSA at different stratifications of severity, based on the apnea-hypopnea index (AHI), was fully evaluated together with the major health ...
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Aug 1, 2014·Hypertension10.19
#1Kamal Rahmouni (Roy J. and Lucille A. Carver College of Medicine)H-Index: 64
The worldwide epidemic of excess body weight, including overweight and obesity, is associated with increased prevalence of cardiovascular risks comprising hypertension—a condition that promotes stroke, heart disease, and end-stage organ damage, which are major causes of death and disability.1,2 The close relationship between excess adipose mass and hypertension is well documented, with population-based studies showing excess adiposity as the strongest known risk factor for hypertension in male a...
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#1Guido GrassiH-Index: 101
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OBJECTIVE: Obstructive sleep apnoea (OSA) is characterized by a marked sympathetic overdrive, as documented by the elevated sympathetic nerve firing rate detected in peripheral muscle nerves. No data are available, however, on the behaviour of sympathetic drive in vascular regional districts other than the muscle circulation. DESIGN AND METHODS: In 66 middle-aged normotensive individuals classified according to BMI, waist-to-hip ratio and apnoea-hypopnea index as lean individuals without (n = 20...
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Feb 1, 2014·Hypertension10.19
#1Tomas Konecny (Gdańsk Medical University)H-Index: 17
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There is growing evidence of a causal relationship between obstructive sleep apnea (OSA) and hypertension. Untreated OSA may have direct and deleterious effects on cardiovascular function and structure through several mechanisms, including sympathetic activation, oxidative stress, inflammation, and endothelial dysfunction. OSA may contribute to or augment elevated blood pressure levels in a large proportion of the hypertensive patient population. It is important to consider OSA in the differenti...
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Obstructive sleep apnea (OSA) is highly relevant to patients with hypertension (HTN). These 2 conditions frequently coexist (an estimated 50% of patients with HTN have concomitant OSA), and recent evidence supports the notion that OSA represents the most prevalent secondary contributor to elevated blood pressure (BP) in patients with resistant HTN (Figure 1).1 Figure 1. Prevalence of secondary causes of hypertension associated with resistant hypertension in a cohort of 125 patients from Brazil. ...
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Which came first, the chicken or the egg? This is a difficult question to answer because defining when the precursor to the chicken became a chicken is impossible, so we can never be sure in which geological strata we should look for fossils. To an extent the same applies to hypertension. At what point does blood pressure become too high and in need of reduction? All definitions we have are artificial numerical thresholds based on a value judgement because they have to cater to entire population...
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Importance Obstructive sleep apnea is a common disease, responsible for daytime sleepiness. Prior to referring patients for definitive testing, the likelihood of obstructive sleep apnea should be established in the clinical examination. Objective To systematically review the clinical examination accuracy in diagnosing obstructive sleep apnea. Data Sources MEDLINE and reference lists from articles were searched from 1966 to June 2013. Titles and abstracts (n = 4449) were reviewed for eligibility ...
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The association between obstructive sleep apnea (OSA) and cardiovascular morbidity and mortality is largely the result of myocardial anomalies. In this Review, the authors discuss the mechanisms that lead to myocardial damage and cardiac dysfunction in patients with OSA, and the potential beneficial effects of nasal continuous positive airway pressure on cardiac symptoms and hemodynamic parameters in these patients.
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Rationale: Obstructive sleep apnea and systemic hypertension (SH) are highly prevalent. Although their association has been suggested in cross-sectional studies, conflicting evidence has emerged from longitudinal studies.Objectives: To assess the association between obstructive sleep apnea and SH in the middle-aged general population.Methods: A total of 2,148 subjects were included in a longitudinal study of the Vitoria Sleep Cohort, a general population sample aged 30–70 years. We analyzed data...
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Cited By3
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Apr 17, 2017·Neurological Research2.45
#1Meiyan Liu (Capital Medical University)H-Index: 2
#2Na Li (Capital Medical University)H-Index: 1
Last. Hajra Khan (WSU: Wayne State University)H-Index: 3
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AbstractAim: The etiology of hypertension is various and complex, involving both genetic and behavioral factors. The relationship between psychosocial stress and hypertension has been hypothesized. More and more people experience increased anxiety, depression, and chronic psychosocial stress brought on by globalization, cultural changes, socioeconomic changes, and stress at the work place. Although a plethora of studies have investigated the interaction between psychosocial stress and hypertensi...
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#1Tsung-I Chen (TCU: Tzu Chi University)H-Index: 1
#2Wei-Chia Tu (TCU: Tzu Chi University)H-Index: 1
Purpose: To investigate the role of sodium–hydrogen exchanger-1 (NHE-1) and exercise training on intermittent hypoxia-induced cardiac fibrosis in obstructive sleep apnea (OSA), using an animal model mimicking the intermittent hypoxia of OSA. Methods: Eight-week-old male Sprague–Dawley rats were randomly assigned to control (CON), intermittent hypoxia (IH), exercise (EXE) or IH combined with exercise (IHEXE) groups. These groups were randomly assigned to subgroups receiving either a vehicle or th...
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