Time Trends of Ischemic Stroke Incidence and Mortality in Patients Diagnosed With First Atrial Fibrillation in 1980 to 2000 Report of a Community-Based Study

Published on Nov 1, 2005in Stroke7.19
· DOI :10.1161/01.STR.0000185927.63746.23
Yoko Miyasaka12
Estimated H-index: 12
(Mayo Clinic),
Marion E. Barnes35
Estimated H-index: 35
(Mayo Clinic)
+ 5 AuthorsTeresa S.M. Tsang56
Estimated H-index: 56
(Mayo Clinic)
Sources
Abstract
Background and Purpose— With the changes in management of atrial fibrillation (AF) over time, it is possible that the time trends of post-AF stroke incidence and mortality have changed. We sought to determine whether the incidence and survival of ischemic stroke after AF diagnosis have improved. Methods— We identified the Olmsted County, Minn, residents who developed first AF from 1980 to 2000 and followed them in medical records to 2004. The outcomes were first ischemic stroke and death. Results— Of the 4117 subjects diagnosed with first AF and without previous stroke, 446 (11%) sustained a first ischemic stroke during a mean follow-up time of 5.5±5.0 years. The age- and sex-adjusted incidence of stroke decreased, on average, by 3.4% per year (P=0.0001), concurrent with an increase in warfarin and aspirin use (both P<0.0001) and reduction of systolic blood pressure (P<0.001). The age-adjusted ischemic stroke incidence was higher in women (P=0.039), but not after adjusting for systolic blood pressure (P=0...
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