Structure-function Relationships Using the Cirrus Spectral Domain Optical Coherence Tomograph and Standard Automated Perimetry

Published on Jan 1, 2012in Journal of Glaucoma2.503
· DOI :10.1097/IJG.0B013E31822AF27A
Mauro T. Leite16
Estimated H-index: 16
 (UCSD: University of California, San Diego), Linda M. Zangwill96
Estimated H-index: 96
 + 3 AuthorsFelipe A. Medeiros84
Estimated H-index: 84
Sources
Abstract
Purpose: To evaluate the relationship between glaucomatous structural damage assessed by the Cirrus Spectral Domain OCT (SDOCT) and functional loss as measured by standard automated perimetry (SAP). Methods: Four hundred twenty-two eyes (78 healthy, 210 suspects, 134 glaucomatous) of 250 patients were recruited from the longitudinal Diagnostic Innovations in Glaucoma Study and from the African Descent and Glaucoma Evaluation Study. All eyes underwent testing with the Cirrus SDOCT and SAP within a 6-month period. The relationship between parapapillary retinal nerve fiber layer thickness (RNFL) sectors and corresponding topographic SAP locations was evaluated using locally weighted scatterplot smoothing and regression analysis. SAP sensitivity values were evaluated using both linear as well as logarithmic scales. We also tested the fit of a model (Hood) for structure-function relationship in glaucoma. Results: Structure was significantly related to function for all but the nasal thickness sector. The relationship was strongest for superotemporal RNFL thickness and inferonasal sensitivity (R2=0.314, P Conclusions: RNFL thinning measured by the Cirrus SDOCT was associated with correspondent visual field loss in glaucoma.
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Newest
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#1Paul H. Artes (Dal: Dalhousie University)H-Index: 29
#2Balwantray C. Chauhan (Dal: Dalhousie University)H-Index: 58
Last. Michael A. Kass (WashU: Washington University in St. Louis)H-Index: 60
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Objective To assess agreement between longitudinal and cross-sectional analyses for determining visual field progression in data from the Ocular Hypertension Treatment Study. Methods Visual field data from 3088 eyes of 1570 participants (median follow-up, 7 years) were analyzed. Longitudinal analyses were performed using change probability with total and pattern deviation, and cross-sectional analyses were performed using the glaucoma hemifield test, corrected pattern standard deviation, and mea...
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The glaucomas are a group of relatively common optic neuropathies, in which the pathological loss of retinal ganglion cells causes a progressive loss of sight and associated alterations in the retinal nerve fiber layer and optic nerve head. The diagnosis and management of glaucoma are often dependent on methods of clinical testing that either, 1) identify and quantify patterns of functional visual abnormality, or 2) quantify structural abnormality in the retinal nerve fiber layer, both of which ...
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Purpose Retinal nerve fiber (RNFL) thickness and visual field loss data from patients with glaucoma were analyzed in the context of a model, to better understand individual variation in structure versus function.
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Sep 1, 2008·Acta Ophthalmologica3.76
#1Shino Sato (Kagawa University)H-Index: 9
#2Kazuyuki Hirooka (Kagawa University)H-Index: 24
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. Purpose: To evaluate the relationship between retinal nerve fibre layer (RNFL) thickness measured by optical coherence tomography (OCT) and light threshold values obtained with the Micro Perimeter 1 (MP1). Methods: Forty-nine normal subjects and 37 glaucoma patients were included. Thickness of the RNFL around the optic disc was measured with Stratus OCT scans, and static threshold perimetry was performed with the MP1 at the same visit. Total average and mean 12-clock-hour RNFL thickness were m...
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Apr 2, 2008·Graefes Archive for Clinical and Experimental Ophthalmology3.12
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Background Pattern electroretinogram (PERG) and optical coherence tomography (OCT) represent objective probes to investigate respectively the function of retinal ganglion cells and their structure as retinal nerve fiber layer (RNFL) thickness. We examined interindividual (II) correlations of PERG amplitude and RNFL thickness, as well as correlations between interocular (IO) differences in both measures, in ocular hypertension (OHT) and early glaucoma (EG) patients.
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Dec 1, 2007·Journal of Glaucoma2.50
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Purpose To investigate the impact of perimetric measurement scales, sample composition, and 2 statistical methods on the structure-function relationship in glaucoma. Methods Three hundred eighty-five eyes of 385 participants, covering the full spectrum of the disease from healthy to advanced glaucoma, were tested with the Heidelberg Retina Tomograph and standard automated perimetry (Swedish Interactive Thresholding Algorithm) within a 6-month period. The associations (R2) between neuroretinal ri...
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Purpose To define the relationship between retinal light sensitivity and peripapillary retinal nerve fiber layer (RNFL) thickness as measured using the Stratus optical coherence tomograph (OCT). Design Prospective study. Methods setting: Institutional. study population: A total of 126 healthy subjects, 42 patients with ocular hypertension (OHT) and 64 patients with primary open-angle glaucoma (POAG) were examined by the 24/II program of the Humphrey Field Analyzer (Carl Zeiss Meditec, Inc, Dubli...
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Purpose To compare the strength of the structure–function association between scanning laser polarimetry-measured retinal nerve fiber layer (RNFL) thickness and visual sensitivity. Two methods of corneal compensation were evaluated, variable corneal compensation (VCC) and enhanced corneal compensation (ECC). Design Observational case series. Participants One hundred twenty-seven glaucoma (repeatable abnormal visual fields [VF] by pattern standard deviation and/or glaucoma hemifield test) or glau...
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Glaucoma, which can cause irreversible damage to the sight of human eyes, is conventionally diagnosed by visual field (VF) sensitivity. However, it is labor-intensive and time-consuming to measure VF. Recently, optical coherence tomography (OCT) has been adopted to measure retinal layers thickness (RT) for assisting the diagnosis because glaucoma makes structural changes to RT and it is much less costly to obtain RT. In particular, RT can assist in mainly two manners. One is to estimate a VF fro...
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