Class-switched B cells display response to therapeutic B cell depletion in rheumatoid arthritis
Abstract
Reconstitution of peripheral blood (PB) B cells after therapeutic depletion with the chimeric anti-CD20 antibody rituximab (RTX) mimics lymphatic ontogeny. In this situation, the repletion kinetics and migratory properties of distinct developmental B-cell stages and their correlation to disease activity might facilitate our understanding of innate and adaptive B-cell functions in rheumatoid arthritis (RA). Thirty-five 'RTX-naïve' RA patients...
Paper Details
Title
Class-switched B cells display response to therapeutic B cell depletion in rheumatoid arthritis
Published Date
Jan 1, 2009
Journal
Volume
11
Issue
3
Pages
R62 - R62
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Notes
History