9 Parathyroid hormone-related protein: A novel gene product

Many factors, such as interleukin 1, transforming growth factor α, tumour necrosis factor α and β, and prostaglandins, have been implicated in the pathogenesis of the humoral hypercalcaemia of malignancy (Mundy and Martin, 1982; Martin and Mundy, 1987; Mundy et al, 1984). Much interest in the past has also centred upon the likelihood of ectopic secretion of PTH in this condition. We have purified a protein (PTHrP) implicated in HHM from a human...