Gene

Cell biology

Cerebellum

Neuroscience

Biology

Transferrin

Neocortex

Transferrin receptor

Endocrinology

Stem cell

Receptor

Choroid plexus

Neural stem cell

Biochemistry

White matter

Radiology

Immunology

Monoclonal antibody

Spinal cord

Anatomy

Cerebellar cortex

Central nervous system

Medicine

Cerebral cortex

clone (Java method)

Antibody

Magnetic resonance imaging

Pathology

Journal of the Neurological Sciences

Using an immunocytochemical method we demonstrated the presence of TfR on adult rat neurons, particularly in the cerebral cortex and brain stem. The monoclonal antibody (mab) against rat TfR (clone OX 26) stained neurons of all cortical layers and in the brain stem where the reaction was most evident. Purkinje cells in the cerebellum and scattered neurons in the gray matter of the cervical spinal cord were weakly stained. Choroid plexus cells also reacted with the mab against TfR whereas oligodendrocytes in the cerebral white matter were faintly outlined by the mab. The presence of TfR on endothelial cells of brain capillaries was here confirmed.

Transferrin receptors in rat central nervous system