Pharmacokinetic evaluation of oral dantrolene in the dog

The pharmacokinetics of dantrolene and its active metabolite, 5‐hydroxydantrolene, after a single oral dose of either 5 or 10 mg/kg of dantrolene was determined. The effects of exposure to dantrolene and 5‐hydroxydantrolene on activated whole‐blood gene expression of the cytokines interleukin‐2 ( IL ‐2) and interferon‐γ ( IFN ‐γ) were also investigated. When dantrolene was administered at a 5 mg/kg dose, peak plasma concentration ( C max ) was...