In vitro activity of omiganan pentahydrochloride tested against vancomycin-tolerant, -intermediate, and -resistant Staphylococcus aureus

Omiganan, a novel topical cationic peptide active against a broad spectrum of bacteria and yeast, is targeted for the prevention of catheter-associated infections. The spectrum of this agent was evaluated against contemporary methicillin-(oxacillin)-resistant Staphylococcus aureus (MRSA; 109 isolates), including subgroups displaying reduced susceptibility to vancomycin. Strain phenotypes included: vancomycin-tolerant (MBC/MIC ratio, ≥...