Hair follicle regeneration in skin grafts: current concepts and future perspectives

Published on Feb 1, 2012in Tissue Engineering Part B-reviews5.724
· DOI :10.1089/TEN.TEB.2011.0064
Seyed Babak Mahjour6
Estimated H-index: 6
(Stevens Institute of Technology),
Fariborz Ghaffarpasand19
Estimated H-index: 19
,
Hongjun Wang35
Estimated H-index: 35
Sources
Abstract
The repair and management of full-thickness skin defects resulting from burns and chronic wounds remain a significant unmet clinical challenge. For those skin defects exceeding 50%–60% of total body surface area, it is impractical to treat with autologous skin transplants because of the shortage of donor sites. The possibility of using tissue-engineered skin grafts for full-thickness wound repair is a promising approach. The primary goal of tissue-engineered skin grafts is to restore lost barrier function, but regeneration of appendages, such as hair follicles, has to be yet achieved. The successful regeneration of hair follicles in immunodeficient mice suggests that creating human hair follicles in tissue-engineered skin grafts is feasible. However, many limitations still need to be explored, particularly enriching isolated cells with trichogenic capacity, maintaining this ability during processing, and providing the cells with proper environmental cues. Current advances in hair follicle regeneration, in...
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