The Healing Effect of Stem Cells Loaded in Nanofibrous Scaffolds on Full Thickness Skin Defects

In this study, we have evaluated the wound-healing effects of unrestricted somatic stem cells loaded in chitosan-cross linked PHBV nanofibrous scaffold, implanted into the full thickness skin defects of rats. Afterwards, the scaffolds were evaluated by structural, microscopic, physical and mechanical assays and cell culture analyses. Defects were treated with the scaffolds without and with USSCs. MTT assay, immunostaining, and wound pathology...