Original paper
Immune self-reactivity triggered by drug-modified HLA-peptide repertoire
Abstract
Human leukocyte antigens (HLAs) are highly polymorphic proteins that initiate immunity by presenting pathogen-derived peptides to T cells. HLA polymorphisms mostly map to the antigen-binding cleft, thereby diversifying the repertoire of self-derived and pathogen-derived peptide antigens selected by different HLA allotypes. A growing number of immunologically based drug reactions, including abacavir hypersensitivity syndrome (AHS) and...
Paper Details
Title
Immune self-reactivity triggered by drug-modified HLA-peptide repertoire
Published Date
May 23, 2012
Journal
Volume
486
Issue
7404
Pages
554 - 558
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Notes
History