Review paper
Prediction of Immunogenicity of Therapeutic Proteins
Abstract
Most protein therapeutics have the potential to induce undesirable immune responses in patients. Many patients develop anti-therapeutic antibodies, which can affect the safety and efficacy of the therapeutic protein, particularly if the response is neutralizing. There are a variety of factors that influence the immunogenicity of protein therapeutics and, in particular, the presence of B- and T-cell epitopes is considered to be of importance. In...
Paper Details
Title
Prediction of Immunogenicity of Therapeutic Proteins
Published Date
Feb 1, 2010
Journal
Volume
24
Issue
1
Pages
1 - 8
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