miR-21 Modulates Cell Apoptosis by Targeting Multiple Genes in Renal Cell Carcinoma

Objectives To explore the mechanism of miR-21 involved in the development of renal cell carcinoma. Methods Cell proliferation and apoptosis were measured after repression of miR-21 expression by antisense oligonucleotides. miR-21 targets were scanned using target prediction programs. After reduction of miR-21, Fas ligand and metalloproteinase inhibitor 3 (TIMP3) expression and luciferase activity were detected by Western blot and luciferase...