Targeted deletion ofNm23/nucleoside diphosphate kinase AandBreveals their requirement for definitive erythropoiesis in the mouse embryo
Abstract
The ubiquitously expressed nucleoside diphosphate kinases (Nm23/NDPK/Awd) are a large family of multifunctional enzymes implicated in nucleic acid metabolism and in normal and abnormal development. Here, we describe the generation and characterization of NDPK A- and B-deficient (Nme1(-/-)/Nme2(-/-)) mice in which >95% of the enzyme activity is eliminated. These mice are undersized, die perinatally, and exhibit a spectrum of hematological...
Paper Details
Title
Targeted deletion ofNm23/nucleoside diphosphate kinase AandBreveals their requirement for definitive erythropoiesis in the mouse embryo
Published Date
Feb 22, 2009
Journal
Volume
238
Issue
3
Pages
775 - 787
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