Metabotropic glutamate receptor

Metabotropic glutamate receptor 6

Class C GPCR

Cell biology

Neuroscience

Biology

Metabotropic glutamate receptor 7

Receptor

Postsynaptic density

Signal transduction

Biochemistry

Metabotropic glutamate receptor 8

Adenylyl cyclase

Glutamate receptor

Metabotropic receptor

Metabotropic glutamate receptor 4

Chemistry

Metabotropic glutamate receptor 2

Metabotropic glutamate receptor 1

Metabotropic glutamate receptor 5

Current Opinion in Pharmacology

Metabotropic glutamate receptors are classified into three groups, primarily on the basis of sequence similarity and whether they positively couple to the phospholipase C cascade or negatively couple to adenylyl cyclases. The past decade of research, drawing on sophisticated molecular approaches, has revealed a multitude of additional intracellular components that assemble as protein scaffolds around neuronal metabotropic glutamate receptors, establishing functional links to postsynaptic density structures, to membrane-bound enzymes and ion channels, and to the nucleus. Characterization of these novel transduction mechanisms is providing new insights into the roles of metabotropic glutamate receptors in the regulation and modulation of diverse functions in the nervous system.

Metabotropic glutamate receptors: intracellular signaling pathways