Current Opinion in Pharmacology
Papers 2,343
1 page of 235 pages (2,343 results)
#1Ralf Regenthal (Leipzig University)H-Index: 22
#2Peijing Rong (Peking Union Medical College)H-Index: 1
Last. Ute Krügel (Leipzig University)H-Index: 31
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Abstract null null In evidence-based pharmacotherapy, the complexity of etiopathogenesis and pathophysiology of mental diseases has attracted comparably little consideration so far. The choice of currently available pharmacotherapies is predominantly guided by specific clinical phenotypes and is limited by low response rates and clinically relevant side effects. null Nutraceuticals typically represent multicomponent compounds and may offer high therapeutic potential, by simultaneously addressing...
#1Cristiana Bianco (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)H-Index: 7
#2Federica Tavaglione (Sahlgrenska University Hospital)
Last. Luca Valenti (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)H-Index: 78
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Abstract null null Nonalcoholic fatty liver disease is the leading cause of chronic liver disease. Genetic predisposition, lifestyle, and metabolic comorbidities concur to nonalcoholic fatty liver disease development and progression to nonalcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma. Improvement in risk stratification and development of effective therapies for nonalcoholic steatohepatitis are key unmet clinical needs. Knowledge emerging from genomics could meet this need. A...
#1Andrea Mario BollaH-Index: 6
#2Vera Usuelli (University of Milan)H-Index: 14
Last. Paolo Fiorina (Boston Children's Hospital)H-Index: 57
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Abstract null null The most effective and physiological way to treat hyperglycemia is to restore beta-cell function and to rescue production of endogenous insulin. Increasing evidence suggests that both type 1 and type 2 diabetes are characterized by a significant defect in beta-cell mass, leading to the manifestation of the disease. Novel alternative approaches are needed to spare and expand beta-cell mass in patients with diabetes. This review sets out to describe the latest findings on how to...
#1K. Vasudevan (Reva Institute of Technology and Management)H-Index: 1
#2D. Thirumal Kumar (Meenakshi Academy of Higher Education and Research)H-Index: 6
Last. Hatem Zayed (Qatar University)H-Index: 24
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Abstract null null The World Health Organization declared Ebola virus disease (EVD) as the major outbreak in the 20th century. EVD was first identified in 1976 in South Sudan and the Democratic Republic of the Congo. EVD was transmitted from infected fruit bats to humans via contact with infected animal body fluids. The Ebola virus (EBOV) has a genome size of ∼18,959 bp. It encodes seven distinct proteins: nucleoprotein (NP), glycoprotein (GP), viral proteins VP24, VP30, VP35, matrix protein VP4...
#1Fanny Salasc (UCBL: Claude Bernard University Lyon 1)
Last. Andrés Pizzorno (UCBL: Claude Bernard University Lyon 1)H-Index: 16
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Abstract null null To face the COVID-19 pandemic, prophylactic vaccines have been developed in record time, but vaccine coverage is still limited, accessibility is not equitable worldwide, and the vaccines are not fully effective against emerging variants. Therefore, therapeutic treatments are urgently needed to control the pandemic and treat vulnerable populations, but despite all efforts made, options remain scarce. However, the knowledge gained during 2020 constitutes an invaluable platform f...
#1Anastasia Manousi (HHU: University of Düsseldorf)H-Index: 2
#2Patrick Küry (HHU: University of Düsseldorf)H-Index: 28
Abstract null null While current multiple sclerosis therapies are focused on immunomodulation, thereby slowing down disease progression, scientific interest has nowadays been shifted toward regenerative therapies aiming at reversing already existing deficits. The application of chemical compounds was proven to be valuable for the understanding of oligodendrogenesis and for exposing mechanisms that can boost remyelination. However, sufficient myelin repair has not been achieved yet, thus undersco...
#1Emily Wuerch (U of C: University of Calgary)
#2Brian Lozinski (U of C: University of Calgary)H-Index: 4
Last. V. Wee Yong (U of C: University of Calgary)H-Index: 80
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Abstract null null Multiple sclerosis is an inflammatory and demyelinating disease of the central nervous system. null While remyelination facilitates functional recovery in animal models, it is limited in people with multiple sclerosis. Thus, multiple strategies have been put forth to promote remyelination, including exercise and medication. Exercise promotes the release of growth factors and induces protein-level changes, while remyelinating medications act through a variety of mechanisms to p...
#1Lumei Huang (Semmelweis University)
#2Beáta Sperlágh (Semmelweis University)H-Index: 55
Abstract null null Schizophrenia is a common psychiatric disorder which affects approximately 1% of the population worldwide. However, the complexity of etiology, treatment resistance and side effects induced by current antipsychotics, relapse prevention, and psychosocial rehabilitation are still to be uncovered. Caffeine, as the world's most widely consumed psychoactive drug, plays a crucial role in daily life. Plenty of preclinical and clinical evidence has illustrated that caffeine consumptio...
#1Avik Majumdar (USYD: University of Sydney)H-Index: 14
#2Jef Verbeek (Katholieke Universiteit Leuven)H-Index: 12
Last. Emmanuel Tsochatzis (Royal Free Hospital)H-Index: 54
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Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and has an estimated global prevalence of 25%. NAFLD is found in up to 80% of people with obesity and over 60% of patients with diabetes. Cardiovascular disease is the main cause of mortality, followed by extra-hepatic cancers and then liver-specific complications of cirrhosis and hepatocellular carcinoma. Lifestyle modification remains the primary intervention in NAFLD. Weight loss achieved through dietar...
#1Justin V Joseph (AU: Aarhus University)H-Index: 2
#2Mathilde S. Blaavand (AU: Aarhus University)
Last. Martin K. Thomsen (AU: Aarhus University)H-Index: 18
view all 5 authors...
Glioblastoma (GBM) is the most prevalent form of primary malignant brain tumor in adults and remains almost invariably lethal owing to its aggressive and invasive nature. There have only been marginal improvements in its bleak survival rate of 12-15 months over the last four decades. The lack of preclinical models that efficiently recapitulate tumor biology and the tumor microenvironment is also in part responsible for the slow phase of translational GBM research. Emerging three-dimensional (3D)...
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