Differential Expression of Proteins in Response to Ceramide-Mediated Stress Signal in Colon Cancer Cells by 2-D Gel Electrophoresis and MALDI-TOF−MS

Comparative cancer cell proteome analysis is a strategy to study the implication of ceramides in the transmission of stress signals. To better understand the mechanisms by which ceramide regulate some physiological or pathological events and the response to the pharmacological treatment of cancer, we performed a differential analysis of the proteome of HCT-116 (human colon carcinoma) cells in response to these substances. We first established...