Original paper
Local Simvastatin Effects on Mandibular Bone Growth and Inflammation
Abstract
Simvastatin has been shown to increase bone growth when applied topically to murine bone; however, it causes considerable soft tissue inflammation at high doses (2.2 mg), making future clinical use problematic. This study evaluated the effect of lower simvastatin doses and cyclooxygenase (COX) synthase inhibitors on tissue inflammation and bone growth in rats and gene expression in mice.Adult female rats were untreated or treated with a single...
Paper Details
Title
Local Simvastatin Effects on Mandibular Bone Growth and Inflammation
Published Date
Nov 1, 2005
Journal
Volume
76
Issue
11
Pages
1861 - 1870
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Notes
History