Potential new targets involved in 1,3-dinitrobenzene induced testicular toxicity

1,3-Dinitrobenzene (DNB) causes testicular injury, particularly to Sertoli cells, and induces apoptosis in the surrounding germinal cells in rodents; however, the mechanisms causing this toxicity are poorly understood. Our studies, using standard and molecular tools, were conducted to better understand the pathogenesis of the testicular effects. Four daily oral doses of 0.1–8 mg/kg/day caused marked testicular lesions in rats from 4 mg/kg/day....