Cassane-type diterpenes from the seeds of Caesalpinia minax with their antineoplastic activity.

Published on Jun 29, 2012in Planta Medica2.687
· DOI :10.1055/S-0032-1314976
Guo-Xu Ma11
Estimated H-index: 11
(Peking Union Medical College),
Xudong Xu21
Estimated H-index: 21
(Peking Union Medical College)
+ 3 AuthorsLi-Yan Ma2
Estimated H-index: 2
(Peking Union Medical College)
Sources
Abstract
Five new cassane-type diterpenes, neocaesalpin AA ( 1 ), neocaesalpin AB ( 2 ), neocaesalpin AC ( 3 ), neocaesalpin AD ( 4 ) and neocaesalpin AE ( 5 ), were isolated from Caesalpinia minax together with three known compounds, 12 α -methoxyl,5 α ,14 β -dihydroxy-1 α ,6 α ,7 β -triacetoxycass-13(15)-en-16,12-olide ( 6 ), spirocaesalmin ( 7 ) and magnicaesalpin ( 8 ). Their structures were elucidated based on 1D and 2D NMR, MS and CD analyses. Compounds 1 – 6 were tested against Hela, HCT-8, HepG-2, MCF-7 and A549 cancer cells and showed moderate cytotoxicity with IC 50 values from 18.4 to 83.9 µM.
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