Five new cassane-type diterpenes, neocaesalpin AA ( 1 ), neocaesalpin AB ( 2 ), neocaesalpin AC ( 3 ), neocaesalpin AD ( 4 ) and neocaesalpin AE ( 5 ), were isolated from Caesalpinia minax together with three known compounds, 12 α -methoxyl,5 α ,14 β -dihydroxy-1 α ,6 α ,7 β -triacetoxycass-13(15)-en-16,12-olide ( 6 ), spirocaesalmin ( 7 ) and magnicaesalpin ( 8 ). Their structures were elucidated based on 1D and 2D NMR, MS and CD analyses. Compounds 1 – 6 were tested against Hela, HCT-8, HepG-2, MCF-7 and A549 cancer cells and showed moderate cytotoxicity with IC 50 values from 18.4 to 83.9 µM.
Last. Huiyuan Gao(SPU: Shenyang Pharmaceutical University)H-Index: 12
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Eighteen cassane diterpenoids, including five new lactam-type (4-8), 12 new lactone-type (1-3 and 9-17), and one known compound (18), were isolated from Caesalpinia sinensis. To our knowledge, this is the first study on the seed kernels of C. sinensis, and cassane derivatives were discovered in this plant for the first time. Their structures including absolute configurations were established by extensive spectroscopic methods complemented with single-crystal X-ray diffraction analyses and ECD ca...
Last. Ligen Lin(UM: University of Macau)H-Index: 27
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Ten new cassane-type diterpenoids were isolated from the seeds of Caesalpinia bonduc (L.) Roxb., including 6α-hydroxycaesalpinin P (1), 14-epi-caesalpinin E1 (2), 6-deacetylcaesalmin Z (3), 14-epi-caesalmin Z (4), caesalpinolides I (5), K (6), L (7), M (9) and N (10), and 14-epi-neocaesalpin L (8). Their planar structures and absolute configurations were fully determined by comprehensive spectroscopic methods, including 2D NMR and electronic circular dichroism spectra. Compounds 1-4 are tetracyc...
Last. Huiyuan Gao(SPU: Shenyang Pharmaceutical University)H-Index: 12
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The first investigation of chemical composition in seed kernels of Caesalpinia cucullata Roxb. resulted in the separation of four new cassane diterpenes, including three furanoditerpenes (1, 2 and 4) and one tricyclic type (3). It was the first found cassane diterpenoids from this plant. Their gross structures were elucidated by means of comprehensive spectroscopic analysis (UV, IR, NMR, HRESIMS) as well as electronic circular dichroism (ECD) calculation. The compound 1 possess a rare isomerized...
Last. Lei Chen(SZU: Shenzhen University)H-Index: 5
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Abstract Background : Glioblastoma multiforme (GBM) is the most frequent, lethal and aggressive tumour of the central nervous system in adults. The discovery of novel anti-GBM agents based on the isocitrate dehydrogenase (IDH) mutant phenotypes and classifications have attracted comprehensive attention. Purpose : Diterpenoids are a class of naturally occurring 20-carbon isoprenoid compounds, and have previously been shown to possess high cytotoxicity for a variety of human tumours in many scient...
#1Lu-Lu Li(Peking Union Medical College)H-Index: 1
#2Long Chen(Peking Union Medical College)H-Index: 1
Last. Jing Qu(Peking Union Medical College)H-Index: 24
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Abstract Detailed phytochemical investigation of the roots of Erythrophleum fordii furnished seven undescribed cassane-type diterpenoids, erythrocassanoids A-E and erythro-norcassanoids A, B and two known clerodane diterpenes, 15-hydroxy-3-cleroden-2-one and methyl ester of 2-oxopopulifolic acid. Their structures were determined by 1D, 2D NMR and HRESIMS analysis. The antiviral activities of these compounds were evaluated. Among them, 15-hydroxy-3-cleroden-2-one and methyl ester of 2-oxopopulifo...
Last. Huiyuan Gao(SPU: Shenyang Pharmaceutical University)H-Index: 12
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Abstract Natural products, especially diterpenoids, are enriched with numerous compounds with a broad spectrum of therapeutic indications, suggesting that functional moieties serve as a core pharmacophore. Cassane diterpenoids (CAs), as the main and characteristic constituents of medical plants in the Caesalpinia genus, have been widely studied due to their bioactivities, and >450 compounds have been reported since the 1960s, including 283 compounds that have been reported in the past decade. Th...
#1Qingfeng Ruan(Guangzhou University of Chinese Medicine)H-Index: 6
#2Xing-Hong Zhou(Guangzhou University of Chinese Medicine)H-Index: 5
Last. Zhongxiang Zhao(Guangzhou University of Chinese Medicine)H-Index: 13
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Abstract Six previously undescribed cassane diterpenoids, named caesalminaxins O-T (1–6), together with 28 known compounds (7–34), were isolated from the seeds of Caesalpinia minax Hance. Their structures, including their absolute configurations were elucidated by extensive spectroscopic analysis, X-ray diffraction, and quantum chemical calculations. Among the undescribed diterpenoids, compound 6 that possessed an unusual enol group at C-7 with a highly deshielded 1H NMR signal was the first exa...
Last. Zhimin Zhao(SYSU: Sun Yat-sen University)H-Index: 6
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Abstract Three new diterpenes, caesalmin U ( 1 ), caesalmin V ( 2 ) and caesalmin W ( 3 ), were isolated from the EtOAc extract of the seeds of Caesalpinia minax Hance. Their structures were mainly characterized on the basis of extensive spectroscopic analyses and comparison with reported data. The inhibitory activities of nitric oxide (NO) production release of RAW 264.7 cells stimulated by lipopolysaccharide (LPS) of compounds 1 - 3 were evaluated, and compound 1 displayed moderate activity wi...
: As therapeutic tools, diterpenes and their derivatives have gained much attention of the medicinal scientists nowadays. It is due to their pledging and important biological activities. This review congregates the anticancer diterpenes. For this, a search was made with selected keywords in PubMed, Science Direct, Web of Science, Scopus, The American Chemical Society and miscellaneous databases from January 2012 to January 2017 for the published articles. A total 28, 789 published articles were ...