Impairment of Skin Wound Healing in β-1,4-Galactosyltransferase-Deficient Mice with Reduced Leukocyte Recruitment

Cell-surface carbohydrate chains are known to contribute to cell migration, interactions, and proliferation, but their roles in skin wound healing have not been evaluated. We examined the biological roles of β4-galactosylated carbohydrate chains in skin wound healing using mutant mice that lack β-1,4-galactosyltransferase-I (β4GalT-I), which is responsible for the biosynthesis of the type 2 chain in N-glycans and the core 2 branch in O-glycans....