HOX-GFP and WOX-GFP lentivirus vectors for inner ear gene transfer

GFP transgene was expressed in the lining cells of the perilymphatic space. Lentivirus vectors are safe and cause only minimal inflammatory reaction. Transgene products can be delivered into the perilymph by utilizing lentivirus vectors.To analyze the efficiency and safety of lentiviral vectors HOX-GFP and WOX-GFP in intracochlear gene transfer.Lentivirus vectors were tested for their transduction efficiency in vivo in CD-1 mice. Half of the...