The broad spectrum of statin myopathy: from myalgia to rhabdomyolysis

The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) are the cornerstone of therapy for dyslipidemia. A significant portion of patients are not adherent to statin therapy, due to either intolerance from muscle symptoms or fears of myopathy reported in the media. The diagnosis and management of patients with statin-induced myopathy will be reviewed.Based on a review of healthy clinical-trial participants, the placebo-corrected...