Rebuild, restore, reinnervate: do human tissue engineered dermo-epidermal skin analogs attract host nerve fibers for innervation?

Thomas Biedermann; Sophie Böttcher-Haberzeth; Agnieszka S. Klar; Luca Pontiggia; Clemens Schiestl; Claudia Meuli-Simmen; Ernst Reichmann; Martin Meuli

doi:https://doi.org/10.1007/s00383-012-3208-1

doi.org/10.1007/s00383-012-3208-1

Rebuild, restore, reinnervate: do human tissue engineered dermo-epidermal skin analogs attract host nerve fibers for innervation?

Thomas Biedermann

27

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Sophie Böttcher-Haberzeth

18

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..., Martin Meuli

37

Pediatric Surgery International1.80

Volume: 29, Issue: 1, Pages: 71 - 78

Published: Nov 13, 2012

Abstract

Tissue engineered skin substitutes are a promising tool to cover large skin defects, but little is known about reinnervation of transplants. In this experimental study, we analyzed the ingrowth of host peripheral nerve fibers into human tissue engineered dermo-epidermal skin substitutes in a rat model. Using varying cell types in the epidermal compartment, we wanted to assess the influence of epidermal cell types on reinnervation of the...