Targeting TGFβ signaling in subchondral bone and articular cartilage homeostasis
Abstract
Osteoarthritis (OA) is the most common degenerative joint disease and no disease-modifying therapy for OA is currently available. Targeting articular cartilage alone may not be sufficient to halt this disease progression. Articular cartilage and subchondral bone act as a functional unit. Increasing evidence indicates that transforming growth factor β (TGFβ) plays a crucial role in maintaining homeostasis of both articular cartilage and...
Paper Details
Title
Targeting TGFβ signaling in subchondral bone and articular cartilage homeostasis
Published Date
May 1, 2014
Volume
35
Issue
5
Pages
227 - 236
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