Original paper
PHASE-I STUDY OF SYNTHETIC MUC1 PEPTIDES IN BREAST-CANCER
Abstract
Exposed peptides in the repeat (VNTR) protein core of human mucin 1 (MUC1) could be a target for immunotherapy, as it is highly immunogenic in mice and a human cytotoxic T lymphocytes to MUC1 recognise the peptide. On this basis 13 patients were immunised with a MUC1 peptide - a 20 amino acids dimer conjugated with diphtheria toroid as carrier. In patients with established breast cancer increasing doses (0.15 mg, 0.25 mg, 0.5 mg, 1.0 mg) were...
Paper Details
Title
PHASE-I STUDY OF SYNTHETIC MUC1 PEPTIDES IN BREAST-CANCER
Published Date
Jun 1, 1995
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Notes
History