Original paper
Semisynthetic Maytansine Analogues for the Targeted Treatment of Cancer
Abstract
Maytansine, a highly cytotoxic natural product, failed as an anticancer agent in human clinical trials because of unacceptable systemic toxicity. The potent cell killing ability of maytansine can be used in a targeted delivery approach for the selective destruction of cancer cells. A series of new maytansinoids, bearing a disulfide or thiol substituent were synthesized. The chain length of the ester side chain and the degree of steric hindrance...
Paper Details
Title
Semisynthetic Maytansine Analogues for the Targeted Treatment of Cancer
Published Date
Jun 10, 2006
Volume
49
Issue
14
Pages
4392 - 4408
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Notes
History