Functional dichotomy of A20 in apoptotic and necrotic cell death
Abstract
ROS (reactive oxygen species) play important roles in the progression of a number of human pathologies. ROS promote cell death, but can also induce gene transcription. The transcription factor NF-κB (nuclear factor κB) plays a critical role in oxidative stress responses. One of the proteins regulated by NF-κB is the zinc-finger protein A20. In TNF (tumour necrosis factor)-α signalling, NF-κB induction of A20 leads to increased cell survival. In...
Paper Details
Title
Functional dichotomy of A20 in apoptotic and necrotic cell death
Published Date
Mar 22, 2005
Journal
Volume
387
Issue
1
Pages
47 - 55
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