Lysine Deacetylases Regulate the Heat Shock Response Including the Age-Associated Impairment of HSF1
Abstract
Heat shock factor 1 (HSF1) is critical for defending cells from both acute and chronic stresses. In aging cells, the DNA binding activity of HSF1 deteriorates correlating with the onset of pathological events including neurodegeneration and heart disease. We find that DNA binding by HSF1 is controlled by lysine deacetylases with HDAC7, HDAC9, and SIRT1 distinctly increasing the magnitude and length of a heat shock response (HSR). In contrast,...
Paper Details
Title
Lysine Deacetylases Regulate the Heat Shock Response Including the Age-Associated Impairment of HSF1
Published Date
Apr 1, 2015
Journal
Volume
427
Issue
7
Pages
1644 - 1654
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