Involvement of transient receptor potential vanilloid 1 receptors in protease‐activated receptor‐2‐induced joint inflammation and nociception

Protease‐activated receptor‐2 (PAR‐2) is a G‐protein‐coupled receptor activated through proteolytic cleavage. It is localized on epithelial, endothelial and inflammatory cells, as well as on transient receptor potential vanilloid 1 (TRPV1) receptor‐expressing neurones. It plays an important role in inflammatory/nociceptive processes. Since there are few reports concerning PAR‐2 function in joints, the effects of intraarticular PAR‐2 activation...