Active ingredient

Engineering

Biology

Materials science

Botany

Chemical engineering

Phosphate

Food science

Geology

Paleontology

Organic chemistry

Bioinformatics

Ingredient

Pharmacology

Composite material

Capsule

Medicine

Chemistry

Granulation

Journal of Pharmaceutical Sciences

A correlation has been shown to exist between the flow properties of clomacran phosphate powder blends and capsule fill weight variation when an automatic capsule-filling machine is used.A correlation of 0.96 was obtained for the capsule mixes tested.Weight variation of the finished capsules is also affected by lot-to-lot variability and concentration of clomacran phosphate.Granulation of the active ingredient overcomes most of the problems normally encountered and provides finished capsules of uniform weight.

Encapsulation of Clomacran Phosphate {2-Chloro-9-[3-(dimethylamino)propyl]acridan Phosphate} I: Effect of Flowability of Powder Blends, Lot-to-Lot Variability, and Concentration of Active Ingredient on Weight Variation of Capsules Filled on an Automatic Capsule-Filling Machine