Expression of the urokinase plasminogen activator receptor is transiently required during ?priming? of PC12 cells in nerve growth factor-directed cellular differentiation
Abstract
We previously identified the urokinase plasminogen activator receptor (UPAR) as a gene induced by nerve growth factor (NGF), but not by epidermal growth factor (EGF), in PC12 cells (Farias-Eisner et al. [2000] J. Neurosci. 20:230-239). Antisense oligonucleotides for the UPAR mRNA or an antibody directed against UPAR protein, added simultaneously with NGF, block NGF-induced morphological and biochemical differentiation of PC12 cells. In this...
Paper Details
Title
Expression of the urokinase plasminogen activator receptor is transiently required during ?priming? of PC12 cells in nerve growth factor-directed cellular differentiation
Published Date
Jan 1, 2001
Volume
63
Issue
4
Pages
341 - 346
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