The role of iron regulatory proteins in mammalian iron homeostasis and disease
Abstract
Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are mammalian proteins that register cytosolic iron concentrations and post-transcriptionally regulate expression of iron metabolism genes to optimize cellular iron availability. In iron-deficient cells, IRPs bind to iron-responsive elements (IREs) found in the mRNAs of ferritin, the transferrin receptor and other iron metabolism transcripts, thereby enhancing iron uptake and decreasing iron...
Paper Details
Title
The role of iron regulatory proteins in mammalian iron homeostasis and disease
Published Date
Jul 18, 2006
Journal
Volume
2
Issue
8
Pages
406 - 414
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