Controlled Release with Finite Dissolution Rate

Volume: 71, Issue: 3, Pages: 731 - 752
Published: Jan 1, 2011
Abstract
We consider a two-phase generalization of the classical Higuchi model for controlled drug release. The drug is assumed to be prepared in a stent in its solid phase by immersion in a polymeric matrix, which eventually delivers the drug when it reaches the free end. We derive a single effective evolution equation, which we prove to be equivalent to the original system of two coupled PDEs. We provide analytical estimates for the asymptotic regimes...
Paper Details
Title
Controlled Release with Finite Dissolution Rate
Published Date
Jan 1, 2011
Volume
71
Issue
3
Pages
731 - 752
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