antioxidant activity

ethyl acetate

radical scavenging

antioxidant activities

mg ml

vitro antioxidant

preliminary phytochemical

Natural Product Research

Thymelaea microphylla Coss. et Dur. (Thymelaeaceae) is a rare medicinal plant endemic to Algeria. In order to continue our studies on this species, herein we report the isolation and characterisation of 20 compounds from a hydroalcoholic extract (EtOH–H2O 7:3) of the aerial parts. They include monoterpene glucosides (1–3), phenolic acid derivatives (4, 8 and 9), phenylpropanoid glucosides (5 and 6), flavonoids (7, 10 and 11), a benzyl alcohol glucoside (12), ionol glucosides (13–16), lignans (17–19) and a bis-coumarin (20). All the structures were elucidated by spectroscopic methods including 1D and 2D NMR experiments, as well as ESI-MS analysis. Moreover, the extract of T. microphylla showed a significant and concentration-dependent free radical-scavenging activity in vitro, correlated to the presence of phenolic and chlorogenic acid derivatives (8, 9 and 4).Keywords:: Thymelaea microphyllapolyphenolslignansionol glucosidesmonoterpenesbis-coumarinfree radical-scavenging activity

Chemical composition and antioxidant activity of a polar extract ofThymelaea microphyllaCoss. et Dur.